Edward Fox as Dr. Macmillan (3 episodes, 1969-1972)
Richard Johnson as Claudius, King of Denmark (3 episodes, 1970-1972)
Geraldine McEwan as Madeleine Desmarest (3 episodes, 1971-1973)
Anna Massey as Christiana Edmunds (4 episodes, 1970-1973)
Jim Dale as Lucifer Kane (6 episodes, 1969)
Billy Murray as Eric (3 episodes, 1969-1972)
Michael Bryant as Anthony Berridge (4 episodes, 1970-1973)
June Brown as Betty (4 episodes, 1969-1973)
John Thaw as Larry (4 episodes, 1969-1973)
Roland Culver as Catherwood (3 episodes, 1969-1973)
Michael Craig as Alan Williams (4 episodes, 1969-1971)
Diane Cilento as Lady Sarah Bellasize (6 episodes, 1969)
Judy Cornwell as Erica Moone (3 episodes, 1970-1973)
Norman Bird as Father (3 episodes, 1969-1973)
James Laurenson as Sam (3 episodes, 1970)
Barbara Leigh-Hunt as Anita Hill (3 episodes, 1969-1970)
Mary Peach as Angela (3 episodes, 1971-1972)
Ray McAnally as Dr. Gebhardt (3 episodes, 1969-1973)
Norman Rossington as Abe (4 episodes, 1969-1970)
Ann Lynn as Brenda Harrison (3 episodes, 1969-1970)
Cyril Luckham as Geoffrey (3 episodes, 1970-1972)
Julia Foster as Sally Blissett (3 episodes, 1971)
Vivien Merchant as Audley (3 episodes, 1969-1970)
Sean Bury as Bob Blissett (4 episodes, 1971-1972)
Ian Hendry as Charles Stanton (3 episodes, 1970-1972)
Geoffrey Bayldon as Finsbury (3 episodes, 1970-1972)
Rachel Kempson as Lady Sankey (3 episodes, 1971-1972)
Pat Heywood as Dora Evans (4 episodes, 1971-1973)
Anna Calder-Marshall as Mary MacNeil (4 episodes, 1969-1971)
Jeremy Longhurst as Temple (3 episodes, 1969)
John Nettleton as Edward (4 episodes, 1969-1973)
Godfrey James as Marcellus (3 episodes, 1969-1971)

Paul Eddington as Lyov (3 episodes, 1972)
Len Jones as Dave Ogden (3 episodes, 1971-1973)
Gwen Watford as Dorrie (4 episodes, 1969-1972)
Anne Tirard as Old Bessie (6 episodes, 1969)
John Welsh as Doctor Hewitson (3 episodes, 1972-1973)
Ann Firbank as Mary (3 episodes, 1970-1972)
John Woodnutt as Doctor Peppercorn (6 episodes, 1969)
Rudolph Walker as Nick (3 episodes, 1969-1970)
Joe Gladwin as Messenger (4 episodes, 1969-1972)
Richard Beckinsale as Angus MacFee (3 episodes, 1971-1972)
Danny Sewell as Gideon (6 episodes, 1969)
Madoline Thomas as Emma (6 episodes, 1970-1971)
Sandra Bryant as Molly Socket (6 episodes, 1969)
Christopher Timothy as Tony Abbott (5 episodes, 1969-1973)
Michael Balfour as Tom Meatyard (7 episodes, 1969)
Suzanne Neve as Ann Terson (5 episodes, 1969-1972)
Charles Rea as Barman (5 episodes, 1969-1972)
Jennifer Hilary as Zo (5 episodes, 1969-1970)
Katie Macleod as Susan Blissett (4 episodes, 1970-1971)
Priscilla Morgan as Eunice Horne (4 episodes, 1970-1972)
Anthony Roye as Club member (3 episodes, 1969-1973)
Colette O'Neil as Daisy (3 episodes, 1969-1973)
Alfred Burke as Edgar (4 episodes, 1970-1972)
Daphne Slater as Delia (3 episodes, 1969-1973)
Anthony Bate as Claud Prentice (3 episodes, 1969-1971)
Dudley Jones as Griffith (3 episodes, 1970-1971)
John Franklyn as Brother Martin (3 episodes, 1969-1973)
Michael Lees as Albert Speer (3 episodes, 1969-1973)
Michael Turner as Arnie (3 episodes, 1969-1973)
Roy Hanlon as Hank (3 episodes, 1969-1972)
Gareth Forwood as Basil Anthony (3 episodes, 1969-1972)
Angela Galbraith as Mrs. Clayton-Vernon (3 episodes, 1970-1972)